The 2nd Tai Situpa (1450-1497) was born in the iron-horse year, into a royal family of Tibet. He was recognized by the 6th Gyalwa Karmapa The Karmapa enthroned him and bestowed to the Tai Situpa the entire lineage. The 6th Karmapa also gave Karma Gon Monastery to be under the complete guidance of the 2nd Tai Situpa. Karma Gon became famous for its collection of Sanskrit texts, artwork and scholarship.

The 2nd Tai Situpa became a tutor to the 7th Gyalwa Karmapa. He visited many parts of Tibet, giving teachings and empowerments. He was highly venerated by the Chinese Emperors and many auspicious signs of accomplishment appeared when he passed away.